Kasturi Pawar*
Current research updates in last decade for α-MSH analogue, Proline-Lysine-Valine (KPV) is provided in this review. KPV, although a small molecule, is extremely hydrophilic to deliver through skin and oral delivery is challenging owing to its enzymatic degradation. Further, a clear mechanism of action for KPV has also not been understood completely. Research investigations that shed light into the mechanistic of KPV action is presented in this review. Further, application of KPV and its
newly found/though derivatives in treating various indications have also been presented. Finally, challenges in further development of KPV based products have also been discussed.
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