Archivos de Patología Clínica

Synchronous multicentric pleomorphic xanthoastrocytoma with anaplastic features: Comparative pathological study between conventional and anaplastic types

Kavita Mardi

Background: Pleomorphic xanthoastrocytoma (PXA) has been considered an astrocytic tumor with a relatively favorable prognosis. However, PXA cases having several recurrent patterns with poor prognosis have been reported in recent years, and a new concept of “PXA with anaplastic features” has been proposed. We present one such case in a 55-year-old male who presented with weakness and numbness of right upper and lower limbs since 3 months along with difficulty in walking as well as difficulty in speaking since then. He also complained of headache since 9 months. Th e magnetic resonance imaging study revealed two well demarcated, hypointense, enhancing lesions in the left parietal and posterior frontal lobes. Clinical and radiological examinations were suggestive of a metastatic neoplasm. A left parietal craniotomy was performed with total excision of the bigger lesion. Th e histopathological findings were of PXA with strong pleomorphic, xanthomatous changes, extensive areas of tumor necrosis and increased mitotic activity. Because of these characteristic findings, a histopathological diagnosis of “PXA with anaplastic features” was given. Synchronous multicentric PXA presents unique challenges since total resection of multifocal tumors can cause significant surgical morbidity. In addition, histological homogeneity among the lesions cannot be confirmed and the welldescribed potential for anaplastic transformation may be increased with multiple lesions. The pathological findings of this case is compared with the two conventional cases of PXA diagnosed in our department in the last 10 years.discontinuities. United depleted triaxial tests emerge as perhaps the most thorough strategies to evaluate the strength, volumetric conduct and disappointment interaction of rocks. Understanding the compressibility of a stone framework and the porousness development initiated by the impacts of keeping pressure is fundamental to accomplish a superior comprehension of the profitable conduct and execution of upgraded hydrocarbon recuperation strategies in characteristic supplies. This examination researches the reasonableness of utilizing of repository sandstone analogs, 3D printed with silica sand, to investigate the conduct of common rocks. A thorough mechanical and water powered portrayal of 3D printed silica sand is tended to by exposing the sandstone analogs to different degrees of restricting pressure and estimating their total volumetric misshapening and penetrability development at every pressure stage