Biología celular: investigación y terapia

Regulation of the Tissue Factor Isoform Expression and Thrombogenicity of HMEC-1 by miR-126 and miR-19a

Andreas Eisenreich and Ursula Rauch

Regulation of the Tissue Factor Isoform Expression and Thrombogenicity of HMEC-1 by miR-126 and miR-19a

Endothelial cells modulate the vascular wall homeostasis and blood thrombogenicity. Inflammatory conditions induce the Tissue Factor (TF) isoform expression and cellular thrombogenicity in endothelial cells. MicroRNAs (miRNAs) posttranscriptionally regulate gene expression. MiRNA-19 (miR-19) was shown to downregulate the TF expression in breast cancer cells. The role of miRNAs, such as miR-19a or the endothelial cellspecific miR-126 in the modulation of the endothelial TF expression and activity is unknown.