Revista internacional de investigación cardiovascular

Circulating Aldosterone Levels and Disease Severity in Pulmonary Arterial Hypertension [Retrieved]

Zeenat Safdar, Aishwarya Thakur, Supriya Singh, Yingqun Ji, Danielle Guffey, Charles G Minard and Mark L Entman

Circulating Aldosterone Levels and Disease Severity in Pulmonary Arterial Hypertension

Objective: It is not known whether aldosterone levels are associated with increased mortality in patients with pulmonary arterial hypertension (PAH). The goal of this study was to determine whether circulating aldosterone levels can predict the severity of (PAH) in terms of hemodynamic characteristics and mortality.

Methods: Patients with stable PAH were prospectively enrolled at the Baylor PH program. The plasma levels of aldosterone and BNP were measured. Clinical, hemodynamic, and outcome data was collected. Mean follow up time from study enrollment to follow up was 39 ± 102 months. Cox proportional hazards model was used to assess time to death.