Fatemeh Pourrajab, Seyed Khalil Forouzannia and Seyed Hossain Hekmatimoghadam
Molecular Aspects Contributing to Clinical Efficiency of Bone Marrow Stem Cell Transplantation
The multifunctional plasticity of bone marrow derived stem cells represents the most favorable for transplantation. The immunosuppressive properties of BMSCs have been demonstrated on a wide range of innate and adaptive immune cells. BMSC have emerged to be one of the most promising candidates for cellular immunotherapy in solid organ transplantation because the reduction of conventional immunosuppression is highly desirable. Particularly, BMSCs are able to migrate to site of inflammation/ stress to balance the cells through the PI3K/Akt pathway. As well as, BMSCs are exclusively recruited to tumor site and inhibit cancerous cells by down-regulation of Wnt signaling and the protein kinases.
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