Revista de Hígado: enfermedades y trasplantes

Cerebral Expression of NKCC1 in Rats with Acute and Chronic Hyperammonemia

Martin Eefsen, Ben Vainer, Hanne Cathrine Bisgaard, and Fin Stolze Larsen

Cerebral Expression of NKCC1 in Rats with Acute and Chronic Hyperammonemia

Acute Liver Failure (ALF) is a severe medical condition, primarily defined by high plasma-ammonia levels, multiorgan failure and development of Hepatic Encephalopathy (HE), while chronic liver failure is defined by chronic low level hyperammonemia and development of HE. Newly research showed that increased cerebral expression of the ion-channel Na+, K+, Cl- co-transporter I (NKCC1) is associated with brain edema development in several medical clinical conditions.