Revista de trastornos genéticos e informes genéticos

Evaluation of Genomic Evidence for Oxidative Stress in Experimental Radiation Nephropathy

Eric P Cohen, Marek Lenarczyk, Brian L Fish, Shuang Jia, Martin J Hessner and John E Moulder

Evaluation of Genomic Evidence for Oxidative Stress in Experimental Radiation Nephropathy

Chronic persistent oxidative stress has been proposed as a mechanism for late radiation injury to normal,tissue. Using biochemical, histological, and pharmacological techniques, we have not been able to confirm this hypothesis for late renal radiation injury. Gene expression may be more revealing,especially since the initial effects of radiation are to damage DNA.